Department of Systems Pharmacology & Translational TherapeuticsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Center of Excellence in Environmental ToxicologyPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Harvard Medical SchoolLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Biostatistics and Computational BiologyHarvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Systems Pharmacology & Translational TherapeuticsCenter for Cancer Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Beth Israel Deaconess Medical CenterGenitourinary Medical Oncology, Boston, Massachusetts, USA. Department of MedicineUniversity of Washington, Seattle, Washington, USA. Fred Hutchinson Cancer Research CenterSeattle, Washington, USA. Department of Systems Pharmacology & Translational TherapeuticsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA penning@upenn.edu.